Publications by authors named "Lauren Norwood"
Article Synopsis
- Phenotypic plasticity can adjust important traits in organisms that aid in their establishment in new environments before they undergo genetic adaptation.
- In a study on Raphanus raphanistrum (a problematic weed), researchers compared weedy populations to non-weedy native populations to explore how plasticity helps in colonizing agricultural fields.
- The findings revealed that many traits were both plastic and genetically different between the weedy and native populations, indicating that plasticity may have facilitated the colonization and adaptation of radish plants in new agricultural settings.
Purpose: Antisense oligonucleotides have been under investigation as potential therapeutics for many diseases, including inherited retinal diseases. Chemical modifications, such as chiral phosphorothioate (PS) backbone modification, are often used to improve stability and pharmacokinetic properties of these molecules. We aimed to generate a stereopure (metastasis-associated lung adenocarcinoma transcript 1) antisense oligonucleotide as a tool to assess the impact stereochemistry has on potency, efficacy, and durability of oligonucleotide activity when delivered by intravitreal injection to eye.
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