Publications by authors named "Lauren N Bailey"
Article Synopsis
- The N-heterocyclic carbene gold catalyst (NHC-AuIPr) facilitates a cycloaddition reaction involving propargyl esters and cyclopentadiene or furan.
- The reaction produces a seven-membered ring through a direct process rather than a multi-step transformation.
- The conditions for this reaction are mild, making it an efficient method for forming complex ring structures.
Macrocyclic propargyl acetates containing a furan ring were prepared by using a CrCl(2)-promoted reaction. In the presence of either a Au(I) or Au(III) catalyst, a tandem 3,3-rearrangement/transannular [4+3] cycloaddition reaction occurred to give propargyl acetates that are regio- and diastereospecific. The regiochemistry of the product is controlled by the position of the acetoxy group in the starting material and the stereochemistry of the reaction depends on the ring size.
View Article and Find Full Text PDF