Publications by authors named "Lauren McClurg"
Article Synopsis
- This study examined the potential of using inosine, a urate precursor, to safely elevate serum urate levels in early Parkinson’s disease (PD) as a way to potentially slow down the progression of disability associated with the disease.
- Conducted from 2009 to 2011, the SURE-PD trial involved 75 participants who were either given inosine or a placebo in a controlled environment, with a focus on monitoring safety, tolerability, and urate elevation over a median follow-up of 18 months.
- Results showed that serious adverse events were either similar or lower in the inosine groups compared to placebo, with high tolerability reported; however, 3 participants experienced
Perinatal choline supplementation in rats is neuroprotective against insults such as fetal alcohol exposure, seizures, and advanced age. In the present study we explored whether dietary choline supplementation may also confer protection from psychological challenges, like stress, and act as a natural buffer against stress-linked psychological disorders, like depression. We previously found that choline supplementation increased adult hippocampal neurogenesis, a function compromised by stress, lowered in depression, and boosted by antidepressants; and increased levels of growth factors linked to depression, like brain-derived neurotrophic factor.
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