Publications by authors named "Lauren M Bishop"
Article Synopsis
- Accurate and reproducible quantification of endogenous lipids is essential for lipidomic studies, but adduct formation during mass spectrometry can complicate this process.
- Different types of diacylglycerol (DAG) adduct ions vary in abundance and ratio across various biological matrices, leading to potential inaccuracies in lipid quantification.
- Combining multiple adduct ion types (specifically [M + NH] and [M + Na]) significantly improves quantification accuracy, reducing estimation errors compared to relying on a single adduct ion.
Large-scale lipidomic analyses have been limited by the cost and accessibility of traditional venipuncture sampling. Microsampling techniques offer a less-invasive and more accessible alternative. From a single drop of blood, plasma separation cards (PSC) deliver two volumetric dried plasma samples which are studied here for profiling endogenous blood lipids.
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