Publications by authors named "Lauren Hu"
Article Synopsis
- - Neurogenesis in the adult hippocampus decreases with age, which can lead to cognitive and emotional issues, and identifying the reasons behind this decline has been challenging.
- - The study reveals that the downregulation of lamin B1, a protein in adult neural stem/progenitor cells (ANSPCs), is responsible for age-related changes in neurogenesis.
- - Lower levels of lamin B1 in ANSPCs not only promote premature differentiation but also lead to reduced neurogenesis and increased anxiety-like behaviors in mice as they age.
Background: The relationships between neighborhood factors (i.e., neighborhood socioeconomic status (nSES) and ethnic enclave) and histologic subtypes of lung cancer for racial/ethnic groups, particularly Hispanics and Asian American/Pacific Islanders (AAPIs), are poorly understood.
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- Nucleoporins, like Nup153, play a crucial role in the nuclear architecture of neural progenitor cells (NeuPCs) and are involved in regulating gene expression during differentiation.
- Nup153 specifically interacts with the transcription factor Sox2, which is essential for maintaining the NeuPCs and influencing their neuronal differentiation pathways.
- The study shows that Nup153 and Sox2 bind to and regulate many genes together, impacting their expression and altering chromatin structure, ultimately guiding cell fate decisions.