Publications by authors named "Lauren Hoffner"

Article Synopsis
  • Sex significantly influences biological processes in the kidneys, showing distinct structural and metabolic differences between males and females, which are essential for biomedical research and drug development.
  • Using advanced kidney-specific arteriovenous metabolomics and transcriptomics, researchers discovered that female kidneys retain higher levels of aldosterone and adapt differently to a ketogenic diet compared to male kidneys.
  • The findings highlight that female kidneys efficiently absorb fatty acids and release 3-hydroxybutyrate, while male kidneys do the opposite, revealing important insights into how sex differences impact disease prevalence and treatment responses in kidney health.
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The loss of E-cadherin, an epithelial cell adhesion molecule, has been implicated in metastasis by mediating the epithelial-mesenchymal transition, which promotes invasion and migration of cancer cells. However, recent studies have demonstrated that E-cadherin supports the survival and proliferation of metastatic cancer cells. Here, we identified a metabolic role for E-cadherin in breast cancer by upregulating the de novo serine synthesis pathway (SSP).

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N-adenosine methylation (mA) is the most abundant mRNA modification that controls gene expression through diverse mechanisms. Accordingly, mA-dependent regulation of oncogenes and tumor suppressors contributes to tumor development. However, the role of mA-mediated gene regulation upon drug treatment or resistance is poorly understood.

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The loss of E-cadherin (E-cad), an epithelial cell adhesion molecule, has been implicated in the epithelial-mesenchymal transition (EMT), promoting invasion and migration of cancer cells and, consequently, metastasis. However, recent studies have demonstrated that E-cad supports the survival and proliferation of metastatic cancer cells, suggesting that our understanding of E-cad in metastasis is far from comprehensive. Here, we report that E-cad upregulates the de novo serine synthesis pathway (SSP) in breast cancer cells.

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