New antimicrobial treatment options for severe Gram-negative infections.

Purpose Of Review: This review will provide rationale for the development of new antibiotics to treat severe or multidrug-resistant (MDR) Gram-negative infections. It will also provide an overview of recently approved and pipeline antibiotics for severe/MDR Gram-negative infections.

Recent Findings: MDR Gram-negative infections are recognized as critical threats by global and national organizations and carry a significant morbidity and mortality risk.