Implementation of a commercial federated network of electronic health record data to enable sponsor-initiated clinical trials at an academic medical center.

Background: A commercial federated network called TriNetX has connected electronic health record (EHR) data from academic medical centers (AMCs) with biopharmaceutical sponsors in a privacy-preserving manner to promote sponsor-initiated clinical trials. Little is known about how AMCs have implemented TriNetX to support clinical trials.

Findings: At our AMC over a six-year period, TriNetX integrated into existing institutional workflows enabled 402 requests for sponsor-initiated clinical trials, 14 % (n = 56) of which local investigators expressed interest in conducting.

Implementation of the Surviving Sepsis Campaign one-hour bundle in a short stay unit: A quality improvement project.

Objective: To improve timely sepsis care by implementing the 2018 Surviving Sepsis Campaign one-hour interventions.

Design: Ten-month prospective quality improvement project.

Setting: A 38-bed short stay unit within an 800-bed hospital in New York City.