Publications by authors named "Lauren Fougner"
Article Synopsis
- New imaging technology called PSMA PET is really good at finding prostate cancer spread compared to older methods like [F]FDG PET.
- This study used special balls to mimic cancer spots and looked at how two different ways of making pictures (OSEM and BSREM) affected how accurately we could see and measure those spots.
- The new "gradient-based segmentation" method was found to be better than the standard 40% method for measuring tumor sizes and activity.*
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a nuclear and mitochondrial protein that in nuclei and in vitro repairs blocked 3' DNA termini such as 3' phosphotyrosine conjugates resulting from stalling of topoisomerase I-DNA intermediates. Its mutation also causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Because Tdp1 colocalizes with mitochondria following oxidative stress, we hypothesized that Tdp1 repairs mitochondrial DNA (mtDNA) and that mtDNA damage mediates entry of Tdp1 into the mitochondria.
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