Publications by authors named "Lauren Fill"
Article Synopsis
- The CDC and ACIP endorse COVID-19 vaccination for patients with inborn errors of immunity (IEI), but there's limited knowledge on its safety and impact on infection severity in these patients.
- A study involving a registry of 1,245 IEI patients across 24 countries was conducted to gather data on vaccination frequency, safety, and effectiveness, revealing that 64.7% were vaccinated, primarily with mRNA vaccines.
- Results showed that vaccinated patients had significantly lower hospitalization and ICU admission rates when infected with COVID-19, indicating that vaccination is both safe and effective in reducing the severity of the disease in IEI patients.
Article Synopsis
- Selective anti-polysaccharide antibody deficiency (SPAD) and the novel primary immunodeficiency (PID) known as XMEN are linked to CD5 B-cell predominance, with recent studies revealing more phenotypic variance due to mutations in the MAGT1 gene.
- A prospective classification update is suggested to accurately reflect the impact of MAGT1 glycobiological defects and to consider past cases that exhibited similar B-cell characteristics.
- Immunological evaluations using flow cytometry and next-generation sequencing confirmed a specific MAGT1 mutation, proposing the need for a revised classification that integrates both SPAD and XMEN insights based on recent findings.
Post Autologous Bone Marrow Transplant Associated With a Resultant Mixed Polyclonal/Monoclonal Hyper-IgG3.
Allergy Rhinol (Providence)
March 2020
There have been few studies illustrating the post immunological phenotype of patients receiving autologous bone marrow transplant (ABMT) for the treatment of diffuse large B-cell lymphoma. High-dose chemotherapy and autologous bone marrow transplantation have been shown to be the only potential curative treatment modalities for B-cell lymphoma. Autologous bone marrow transplantation, although widely utilized in patients with non-Hodgkin lymphoma recurrence, does have an association with immunologic side effects, although serologic changes where rarely reported unless accompanied by recurrent infections.
View Article and Find Full Text PDF