Publications by authors named "Lauren Elizabeth Millichap"
Article Synopsis
- Neurodegenerative diseases often impair nervous system function due to mitochondrial dysfunction and oxidative stress, which are major contributors to neurodegeneration.
- The brain is particularly vulnerable to oxidative damage because of its high energy needs and weak antioxidant defenses, leading to further tissue damage and neuroinflammation when imbalances occur.
- Targeting mitochondrial dysfunction through pharmacological interventions, like enhancing mitochondrial biogenesis or activating antioxidant pathways, has emerged as a promising therapeutic strategy to mitigate neurodegeneration, with compounds like natural polyphenols and Nrf2 activators showing potential benefits.
The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge on Coenzyme Q's role in health and disease. Classical antioxidant and bioenergetic functions of the coenzyme have been taken into consideration, as well as novel mechanisms of action involving the redox-regulated activation of molecular pathways associated with anti-inflammatory activities. Cardiovascular research and fertility remain major fields of application of Coenzyme Q, although novel applications, in particular in relation to topical application, are gaining considerable interest.
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