Publications by authors named "Lauren E Merchant"
Article Synopsis
- p53 is a crucial tumor suppressor that controls cell processes like growth and apoptosis through gene regulation, and its dysfunction is frequently linked to cancer.
- This study investigates how the p53-independent integrated stress response (ISR) can be used as a potential cancer treatment, revealing that both p53 and ISR influence similar genes related to metabolism and cell death.
- The research identifies key transcription factors that govern the regulation of these shared genes, providing valuable insights into gene networks targeted by various cancer therapies.
The master tumor suppressor p53 regulates multiple cell fate decisions, like cell cycle arrest and apoptosis, via transcriptional control of a broad gene network. Dysfunction in the p53 network is common in cancer, often through mutations that inactivate p53 or other members of the pathway. Induction of tumor-specific cell death by restoration of p53 activity without off-target effects has gained significant interest in the field.
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