The Effects of poly-GA and poly-PR Dipeptide Repeats on Sleep Patterns in .

is the most common familial gene associated with amyotrophic lateral sclerosis (ALS). Dipeptide repeats (DPRs) encoded by an expanded nucleotide repeat sequence in the gene were found in the sleep-related neurons of patients, indicating a role of DPRs in ALS-associated sleep disruptions. Poly-GA or poly-PR DPRs were expressed in male to study their effect on sleep Poly-PR expression caused sleep disruptions while poly-GA expression did not.