Publications by authors named "Lauren B Crowe"

One limitation to engaging K-12 students and the public with microorganisms is the inability to cultivate and dispose of bacterial and fungal samples safely without expensive equipment or services. This barrier has been amplified with remote learning modalities and laboratory closures driven by safety precautions due to the COVID-19 pandemic. At-home lab kits are being used to bring hands-on experience in microorganism cultivation to students learning remotely, but these kits often fail to take into full consideration the safety aspects or the costs associated with microorganism disposal, limiting which experiments can be performed at home.

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Glial astrocytes of vertebrates and invertebrates are important modulators of nervous system development, physiology, and behavior. In all species examined, astrocytes of the adult brain contain conserved circadian clocks, and multiple studies have shown that these glial cells participate in the regulation of circadian behavior and sleep. This short review summarizes recent work, using fruit fly (Drosophila) and mouse models, that document participation of astrocytes and their endogenous circadian clocks in the control of rhythmic behavior.

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Endogenous rhythmic behaviors are evolutionarily conserved and essential for life. In mammalian and invertebrate models, well-characterized neuronal circuits and evolutionarily conserved mechanisms regulate circadian behavior and sleep [1-4]. In Drosophila, neuronal populations located in multiple brain regions mediate arousal, sleep drive, and homeostasis (reviewed in [3, 5-7]).

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Article Synopsis
  • Extracellular heat shock protein 90 (eHsp90) levels in tumor cells are linked to the severity of malignancy, making it a potential biomarker for early cancer detection.
  • Researchers created a far-red fluorophore-tagged inhibitor that can specifically identify eHsp90 within living organisms.
  • Observations show that eHsp90 accumulates on the surfaces of breast tumor cells and its internalization, which relates to the aggressiveness of the tumors, could provide a unique target for early diagnosis and targeted therapy.
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