Publications by authors named "Lauren A Sexton"
Article Synopsis
- Photoreceptor cells in the retina are specially structured for effective light detection, with rhodopsin as the key pigment in rod cells, which is crucial for vision.
- The renewal and maintenance of rhodopsin occur in the rod inner segment, but its organization and transport mechanisms have not been well defined.
- Using advanced imaging techniques, researchers discovered that rhodopsin molecules are evenly distributed along the inner segment's plasma membrane, indicating a vital pathway for rhodopsin transport in mouse rod photoreceptors.
Photoreceptor cells in the vertebrate retina have a highly compartmentalized morphology for efficient long-term phototransduction. Rhodopsin, the visual pigment in rod photoreceptors, is densely packaged into the rod outer segment sensory cilium and continuously renewed through essential synthesis and trafficking pathways housed in the rod inner segment. Despite the importance of this region for rod health and maintenance, the subcellular organization of rhodopsin and its trafficking regulators in the mammalian rod inner segment remain undefined.
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