Publications by authors named "Lauren A Ray"
Article Synopsis
- Ovarian Sertoli cell tumors are rare sex cord stromal tumors, especially in prepubertal children, and this case involves a girl initially misdiagnosed with McCune-Albright syndrome.
- The 2.5-year-old patient presented with early breast development and vaginal bleeding, with diagnostic tests showing elevated estrogen levels and advanced bone age, ultimately leading to the discovery of an ovarian tumor.
- Pathology confirmed the tumor as a lipid-rich Sertoli cell tumor, and genetic testing revealed a pathogenic variant associated with Peutz-Jeghers syndrome, making her the youngest reported case of precocious puberty caused by this specific tumor linked to PJS.
Objectives: The histrelin implant has been used to treat central precocious puberty (CPP) for more than 15 years. Although approved for annual use, limited published reports suggest that a single implant is efficacious well beyond a year. Our objective was to report our long-term experience using a single histrelin implant for more than 12 months in children with CPP.
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