Publications by authors named "Lauren A Keith"
Article Synopsis
- - Hemorrhagic smallpox, caused by the variola virus, was a nearly 100% fatal disease in humans and often involved serious complications like bacterial infections and bleeding in the heart.
- - Previous studies showed that exposing macaques to the cowpox virus (CPXV) can replicate the effects of human hemorrhagic smallpox for research purposes.
- - This experiment aimed to investigate heart-related issues, finding evidence of acute myocarditis in the CPXV model, which may play an important role in the severity of the disease.
Background: Lung cancer risk prediction models do not routinely incorporate imaging metrics available on low-dose CT (LDCT) imaging of the chest ordered for lung cancer screening.
Research Question: What is the association between quantitative emphysema measured on LDCT imaging and lung cancer incidence and mortality, all-cause mortality, and airflow obstruction in individuals who currently or formerly smoked and are undergoing lung cancer screening?
Study Design And Methods: In 7,262 participants in the CT arm of the National Lung Screening Trial, percent low attenuation area (%LAA) was defined as the percentage of lung volume with voxels less than -950 Hounsfield units on the baseline examination. Multivariable Cox proportional hazards models, adjusting for competing risks where appropriate, were built to test for association between %LAA and lung cancer incidence, lung cancer mortality, and all-cause mortality with censoring at 6 years.