Publications by authors named "Lauren A Alt"
Article Synopsis
- The study highlights the urgent need for effective antimicrobials due to rising antimicrobial-resistant bacteria and investigates the antibacterial properties of silver nanoparticles (AgNPs).
- AgNPs were found to exhibit strong antibacterial efficacy against various resistant bacterial strains, demonstrating bactericidal activity at low concentrations without causing harm to mammalian cells.
- The research also revealed that AgNPs could enhance the effectiveness of antibiotics, significantly reducing the required concentrations of aminoglycosides, while remaining non-toxic to human cells.
Epstein-Barr virus Latent Membrane Protein 2A (LMP2A) is expressed in EBV-infected B cells in the germinal center, a site of significant apoptosis induced by engagement of Fas on activated B cells. Signals from the B cell receptor (BCR) protect germinal center B cells from Fas-mediated apoptosis, and since LMP2A is a BCR mimic, we hypothesized that LMP2A would also protect B cells from Fas-mediated apoptosis. Surprisingly, latently-infected human and murine B cell lines expressing LMP2A were more sensitive to Fas-mediated apoptosis, as determined by increases in Annexin-V staining, and cleavage of caspase-8, -3 and PARP.
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