Development of Psychiatric Residents as Psychotherapists: Effectiveness of a Psychotherapy Pathway.

Objective: This study aimed to assess the effectiveness and impact of participation by psychiatric residents in an academic institution's tiered psychotherapy pathway.

Methods: The authors invited pathway graduates who earned an area of distinction between 2013 and 2020 (N=22) to complete an anonymous online survey about their pathway experiences.

Results: Thirteen graduates (59%) responded to the survey.

Depression in cognitive impairment.

Depression and cognitive disorders, including dementia and mild cognitive impairment, are common in the elderly. Depression is also a common feature of cognitive impairment although the symptoms of depression in cognitive impairment differ from depression without cognitive impairment. Pre-morbid depression approximately doubles the risk of subsequent dementia.

In Six-month-old Infants, Prenatal Exposure to Maternal Anxiety is Associated with Less Developed Smooth Pursuit Eye Movements: An Initial Study.

Aims: There are an increasing number of reports suggesting an association between maternal anxiety experienced during pregnancy and adverse outcomes of the offspring. However, exploration of the biological changes in the brain that mediate that relationship has been hampered by the lack of appropriate biomarkers. This report represents an initial step exploring whether a potential infant biomarker, smooth pursuit eye movements, may be associated with prenatal exposure to maternal anxiety.

Design of a heterotetrameric coiled coil.

We have successfully designed a simple peptide sequence that forms highly stable coiled-coil heterotetramers. Our model system is based on the GCN4-pLI parallel coiled-coil tetramer, first described by Kim and coworkers (Harbury et al., Science 1993;262:1401-1407).