Development of Psychiatric Residents as Psychotherapists: Effectiveness of a Psychotherapy Pathway.

Objective: This study aimed to assess the effectiveness and impact of participation by psychiatric residents in an academic institution's tiered psychotherapy pathway.

Methods: The authors invited pathway graduates who earned an area of distinction between 2013 and 2020 (N=22) to complete an anonymous online survey about their pathway experiences.

Results: Thirteen graduates (59%) responded to the survey.

Depression in cognitive impairment.

Depression and cognitive disorders, including dementia and mild cognitive impairment, are common in the elderly. Depression is also a common feature of cognitive impairment although the symptoms of depression in cognitive impairment differ from depression without cognitive impairment. Pre-morbid depression approximately doubles the risk of subsequent dementia.

Design of a heterotetrameric coiled coil.

We have successfully designed a simple peptide sequence that forms highly stable coiled-coil heterotetramers. Our model system is based on the GCN4-pLI parallel coiled-coil tetramer, first described by Kim and coworkers (Harbury et al., Science 1993;262:1401-1407).