HLA-DR and ICAM-1 expression and modulation in epithelial cells from nasal polyps.

Objective/hypothesis: Through human leukocyte antigen-DR (HLA-DR) and intercellular adhesion molecule-1 (ICAM-1) expression, nasal epithelial cells could actively participate in the chronic inflammation and eosinophil infiltration observed in nasal polyps. The objective of the study was to evaluate HLA-DR and ICAM-1 expression in polyp epithelium and in a culture model of polyp epithelial cells allowing ciliated and secretory differentiation.

Study Design: Prospective non-randomized controlled in vitro study.