Liver iron overload is associated with elevated SHBG concentration and moderate hypogonadotrophic hypogonadism in dysmetabolic men without genetic haemochromatosis.

Aims: To assess the relation between moderate iron overload on sex hormone binding globulin (SHBG) levels and gonadotroph function in men with dysmetabolic iron overload syndrome and the effects of phlebotomy.

Methods: The relationship between magnetic resonance imaging assessed liver iron concentration (LIC) and plasma ferritin levels with total testosterone, bioavailable testosterone (BT), SHBG and LH levels, were studied in 50 men with moderate dysmetabolic iron excess, in the absence of genetic haemochromatosis, who were randomised to phlebotomy therapy or to normal care.

Results: Four patients (8%) had low total testosterone (<10.

[Managing diabetes in cancer patients].

Cancer is a situation which generates a risk of the onset or destabilisation of diabetes. Glycemic goals and treatments must be adapted to the patient's prognosis and regularly reassessed. Renutrition forms part of the support care and requires adjustments to be made to the hypoglycaemic treatments.

Place of cabergoline in acromegaly: a meta-analysis.

Context: Cabergoline is widely considered to be poorly effective in acromegaly.

Objective: The aim of this study was to obtain a more accurate picture of the efficacy of cabergoline in acromegaly, both alone and in combination with somatostatin analogs.

Design: We systematically reviewed all trials of cabergoline therapy for acromegaly published up to 2009 in four databases (PubMed, Pascal, Embase, and Google Scholar).