Publications by authors named "Laure Lacan"
Objective: Few studies have evaluated the efficacy of antiseizure medications (ASMs) according to the etiology of neonatal acute provoked seizures. We aimed to investigate the response to ASMs in term/near term neonates with acute arterial ischemic stroke (AIS), as well as the type of seizure at presentation and the monitoring approach.
Methods: We retrospectively evaluated neonates from 15 European level IV neonatal intensive care units who presented with seizures due to AIS and were monitored by continuous electroencephalography (cEEG) and/or amplitude-integrated EEG (aEEG) in whom actual recordings, timing, doses, and response to ASMs were available for review.
Objective: Currently, fetal monitoring during labor is based on visual analysis of the fetal heart rate (FHR). This test is imperfect, with high intra- and inter-observer variability and a moderate to poor prediction of the occurrence of neonatal acidosis or anoxic-ischaemic encephalopathy. In situations where there is an intermediate risk of acidosis, it is possible to use second-line tests such as blood scalp sampling (with pH or lactate measurement) or ST segment analysis of the fetal ECG.
View Article and Find Full Text PDFObjective: The study aimed to address the challenge of early assessment of neonatal hypoxic-ischemic encephalopathy (HIE) severity to identify candidates for therapeutic hypothermia (TH). The objective was to develop an automated classification model for neonatal EEGs, enabling accurate HIE severity assessment 24/7.
Methods: EEGs recorded within 6 h of life after perinatal anoxia were visually graded into 3 severity groups (HIE French Classification) and quantified using 6 qEEG markers measuring amplitude, continuity and frequency content.
Perinatal anoxia remains an important public health problem as it can lead to hypoxic-ischaemic encephalopathy (HIE) and cause significant neonatal mortality and morbidity. The mechanisms of the fetal brain's response to hypoxia are still unclear and current methods of in utero HIE prediction are not reliable. In this study, we directly analysed the brain response to hypoxia in fetal sheep using in utero EEG.
View Article and Find Full Text PDFObjectives: Controlled therapeutic hypothermia (CTH) is a standard of care in the management of neonatal hypoxic-ischemic encephalopathy HIE in newborns after 36 weeks of gestational age (WGA) in France. The electroencephalogram (EEG) plays a major role in HIE diagnosis and follow-up. We conducted a French national survey on the current use of EEG in newborn undergoing CTH.
View Article and Find Full Text PDFIntroduction: This study evaluated the association between fetal heart rate variability (HRV) and the occurrence of hypoxic-ischemic encephalopathy in a fetal sheep model.
Material And Methods: The experimental protocol created a hypoxic condition with repeated cord occlusions in three phases (A, B, C) to achieve acidosis to pH <7.00.
Objectives: Our objective was to evaluate the potential additional value of electroencephalogram (EEG) and evoked potentials in neonates with hypoxic-ischemic encephalopathy to predict their disability at 1 and 2 years old.
Methods: 30 full-term infants after perinatal asphyxia who underwent therapeutic hypothermia were evaluated at 1 year and 2 years for disability using International Classification of Functioning, Disability and Health classification. Scores for EEG, sensory evoked potentials and brainstem auditory evoked potentials were evaluated after withdrawal of therapeutic hypothermia that lasted 72 h.
Changes in S100B and troponin levels in a fetal sheep model of worsening acidosis.
Eur J Obstet Gynecol Reprod Biol
September 2021
Article Synopsis
- S100B and cardiac troponin T (c-TnT) are important biomarkers indicating potential brain and heart issues in newborns affected by reduced oxygen during childbirth.
- In an experimental model simulating labor-like acidosis, repeated umbilical cord occlusions (UCOs) were used to observe changes in these biomarkers under varying levels of acidosis.
- Results showed significant increases in S100B and c-TnT levels with increasing severity of acidosis, suggesting potential neurological damage and cardiovascular adaptation in the fetus.
Article Synopsis
- The study aimed to identify key quantitative measures from conventional EEGs that can help classify the severity of neonatal hypoxic-ischemic encephalopathy (HIE) shortly after birth.
- Researchers analyzed 90 EEGs from full-term infants, categorizing them into three groups based on HIE severity and finding that six specific EEG parameters could differentiate between these groups with up to 70% accuracy.
- The findings suggest that these EEG measures can serve as important early indicators of HIE severity, and the lack of difference in pH and lactate levels highlights the importance of using EEG for better clinical assessment.
Fetal sheep cerebral electrical activity: A new technique to record EEG.
J Neurosci Methods
November 2020
Background: Sheep models are commonly used to study fetal cortical activity, including response to hypoxia. The standard technique consists of recording electrocorticogram (ECOG) in utero using electrodes placed on the dura mater.
New Method: We propose a new method for recording the electroencephalogram (EEG) of fetal sheep, using electrodes placed above the skull bone and fixed to the cranial periosteum.