Publications by authors named "Laure Frumholtz"
Background: Cutaneous polyarteritis nodosa is a form of medium-sized vessel vasculitis. Despite a disabling and prolonged course, data on treatment efficacy and safety remain scarce.
Objectives: We aimed to describe treatment efficacy and safety in patients with cutaneous polyarteritis nodosa.
Article Synopsis
- Gastrointestinal (GI) involvement in systemic necrotizing vasculitis is linked to a poor prognosis, and its impact can differ based on clinical presentation and specific vasculitis subtypes.
- A study assessed 213 patients with various types of vasculitis who had GI complications, finding that 39% experienced severe outcomes like ICU admission, surgery, or death within six months.
- Key risk factors for these poor outcomes included specific vasculitis subtype (especially polyarteritis nodosa), certain symptoms (like abdominal guarding and melena), and lab results (like high leukocyte counts and low hemoglobin levels), leading to the development of an effective risk prediction model.
Cutaneous Vasculitis: Review on Diagnosis and Clinicopathologic Correlations.
Clin Rev Allergy Immunol
October 2021
Article Synopsis
- Cutaneous vasculitis is an inflammatory condition affecting the blood vessels in the skin, making the skin a key area for diagnosis and examination through accessible biopsies.
- It can represent various forms, ranging from a skin-limited condition to an indication of systemic vasculitis, with lesions that vary in appearance based on the size and location of the affected vessels.
- Understanding skin vascular anatomy and the types of lesions and inflammatory infiltrates is essential for accurate diagnosis, alongside recommended additional tests for skin lesions indicative of vasculitis.
Article Synopsis
- The text presents a case of a patient with systemic lupus erythematosus (SLE) who developed skin lesions similar to those seen in chronic HTLV-1 infections.
- It implies that certain patients with lupus might experience immune system issues that are comparable to those caused by HTLV-1.
- This finding highlights a potential link between HTLV-1 and autoimmune conditions like lupus, suggesting a need for further research.
Article Synopsis
- MAIT cells, which play a role in antibacterial immunity, are found to be significantly decreased in patients with active Dermatomyositis (DM) and Systemic Lupus Erythematosus (SLE), compared to healthy controls and other skin diseases.
- A study compared the frequencies and characteristics of MAIT cells in DM patients (both active and inactive) alongside other conditions, revealing a dramatic drop in MAIT cell levels in active DM (0.25%) compared to healthy individuals (2.32%).
- The MAIT cells from active DM patients also showed an abnormal phenotype, with increased markers of activation that indicate a possible link to their low frequency and increased risk of cell death
Article Synopsis
- Cutaneous manifestations (CM) are common in ANCA-associated vasculitides (AAV), with varying frequencies and types seen in different forms like EGPA, MPA, and GPA.
- A study of 1553 AAV patients found specific lesions associated with each type; for instance, oral ulcers were more common in GPA, while urticarial lesions were frequent in EGPA.
- Overall, CM indicated a worse prognosis in GPA, and while pathological analyses showed inflammation, distinct features were not identified for each AAV type, highlighting how lesion types affect granuloma organization.
Article Synopsis
- The study aimed to identify factors that predict treatment success in syphilitic uveitis (SU) by analyzing a group of 66 patients.
- A retrospective analysis revealed that early improvement in inflammation was a strong indicator of recovery, while certain treatments like periocular dexamethasone and methylprednisolone pulses negatively impacted outcomes.
- The findings suggest that 65% of eyes showed recovery at 1 month, with the majority of cases being panuveitis and posterior uveitis, particularly among HIV+ patients.