Publications by authors named "Laure Duprat"
Background: Skin aging is characterized by slacking and loss of density, especially under ultraviolet (UV) radiation exposure.
Objective: To investigate the beneficial effects of a combination containing bakuchiol (BK) and vanilla tahitensis extract (VTE) to prevent skin photoaging in vitro and to improve clinical outcomes for naturally aged skin.
Materials And Methods: Human dermal fibroblasts were treated with active compounds, exposed to an acute dose of UVA and analyzed by confocal microscopy: actin network for morphology, interleukin-8 (IL-8) for inflammation and p16 for senescence.
Article Synopsis
- - This study explores xenobiotic metabolizing enzymes (XMEs) in a skin model derived from hair follicle outer root sheath (ORS-RHE), showing that its gene expression aligns with that of actual human skin, particularly noting the presence of Cytochromes P450 (CYPs).
- - The ORS-RHE model exhibited strong gene expression for Phase I XMEs like alcohol/aldehyde dehydrogenases and (carboxyl) esterases, and was responsive to known CYP inducers after both topical and systemic applications.
- - Functional assessments revealed that Phase II XMEs, such as GSTs and transferases, were more abundant, and various substances were rapidly metabolized, indicating that ORS-R
A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies.
Clin Cosmet Investig Dermatol
February 2017
Introduction: Natural aging of skin tissues, the addition of the cumulative action of the time and radiation exposure result in skin atrophy, wrinkles and degeneration of the extracellular matrix (ECM). The aim of the study was to investigate the beneficial effect of a combination containing retinaldehyde (RAL), delta-tocopherol glucoside (delta-TC) and glycylglycine ole-amide (GGO) and of a dermocosmetic containing the combination.
Materials And Methods: The protective effect of the combination was assessed through in vitro gene expression of ultraviolet (UV)-irradiated fibroblasts.