Publications by authors named "Laure Dossus"
Association between chronic long-term exposure to airborne dioxins and breast cancer.
Int J Hyg Environ Health
January 2025
Article Synopsis
- Breast cancer is the most common cancer in women, and environmental pollutants, particularly endocrine disruptors like dioxins, may influence its development.
- A study analyzed the link between airborne dioxin exposure and breast cancer risk in a cohort of 5222 cases and 5222 controls, using data about their proximity to dioxin sources and other factors.
- The results indicate a slight increase in breast cancer risk with higher cumulative dioxin exposure, suggesting the need for measures to reduce air pollution exposure.
Background: An increasing number of studies in recent years investigate various dietary and lifestyle patterns and associated breast cancer (BC) risk.
Objectives: This study aimed to comprehensively synthesize and grade the evidence on dietary and lifestyle patterns and BC risk.
Methods: Databases were systematically searched up to 31 March, 2022, for evidence from randomised controlled trials and prospective cohort studies on adherence to a dietary pattern alone or in combination with lifestyle behaviors and incidence of or mortality from primary BC in adult females.
Article Synopsis
- Inflammation plays a significant role in breast cancer progression and prognosis, particularly through pre-diagnostic plasma biomarkers in women.
- A study involving 1,538 women showed that elevated levels of the inflammatory marker IL-6 were linked to increased risks of all-cause and breast cancer-specific mortality, especially in postmenopausal women.
- Higher levels of IL-10 and TNFα were also associated with all-cause mortality, and an inflammatory score could indicate poorer long-term survival, particularly in postmenopausal breast cancer survivors.
Article Synopsis
- Obesity is linked to increased cancer risk, but differences in risk based on metabolic health status are not well understood; this study reviews associations between different metabolic obesity types and cancer risk.
- Researchers screened over 15,500 records, ultimately including 31 studies, with most being at low risk of bias; findings indicate that metabolically unhealthy overweight/obese individuals are at a higher risk for overall and certain specific cancers compared to metabolically healthy normal-weight individuals.
- Specific cancers with increased risk among metabolically unhealthy overweight/obese, include endometrium (2.31 times), kidney (1.71 times), and breast cancers, with varying levels of certainty in the data.
Association of body shape phenotypes and body fat distribution indexes with inflammatory biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank.
BMC Med
August 2024
Article Synopsis
- The study aimed to compare traditional and novel body shape indexes (like ABSI and HI) regarding their associations with inflammation markers, particularly C-reactive protein (CRP), using data from the EPIC and UK Biobank cohorts.
- Participants included nearly 444,000 individuals, with the analysis involving various body shape phenotypes derived from measurements such as height and weight.
- Results indicated that traditional measures like BMI and waist circumference were positively linked to CRP levels, while some body phenotypes showed varying associations by sex, highlighting the complexity of body shape and inflammation relationships.
The adiposity influence on colorectal cancer prognosis remains poorly characterised. We performed a systematic review and meta-analysis on post-diagnosis adiposity measures (body mass index [BMI], waist circumference, waist-to-hip ratio, weight) or their changes and colorectal cancer outcomes. PubMed and Embase were searched through 28 February 2022.
View Article and Find Full Text PDFPost-diagnosis adiposity, physical activity, sedentary behaviour, dietary factors, supplement use and colorectal cancer prognosis: Global Cancer Update Programme (CUP Global) summary of evidence grading.
Int J Cancer
August 2024
Article Synopsis
- A systematic review was conducted on factors like body weight, physical activity, and diet, to evaluate their impact on colorectal cancer prognosis, analyzing 167 publications, mostly observational studies.
- The evidence indicated a complex, reverse J-shaped relationship between body mass index and cancer prognosis, but overall evidence quality was conservative due to potential biases.
- Limited-suggestive findings were noted for recreational physical activity and healthy dietary patterns in reducing mortality risks, highlighting the need for more robust studies to develop effective lifestyle recommendations for colorectal cancer patients.
Purpose: Breast cancer (BC) characteristics are known to influence patients survival. Social differences have been reported by previous studies for those characteristics but questions persist because of inconsistent conclusions. We aimed to investigate the impact of education on BC stage, grade, and hormone receptor (HR) status, while adjusting for potential confounders including a broad set of health behaviors, anthropometric measures, and reproductive factors.
View Article and Find Full Text PDFIn this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity.
View Article and Find Full Text PDFPurpose: There is strong evidence that leisure-time physical activity is protective against postmenopausal breast cancer risk but the association with premenopausal breast cancer is less clear. The purpose of this study was to examine the association of physical activity with the risk of developing premenopausal breast cancer.
Methods: We pooled individual-level data on self-reported leisure-time physical activity across 19 cohort studies comprising 547,601 premenopausal women, with 10,231 incident cases of breast cancer.
Selenium (Se) may help prevent breast cancer (BC) development. Owing to limited observational evidence, we investigated whether prediagnostic Se status and/or variants in the selenoprotein genes are associated with BC risk in a large European cohort. Se status was assessed by plasma measures of Se and its major circulating proteins, selenoprotein P (SELENOP) and glutathione peroxidase 3 (GPX3), in matched BC case-control pairs (2208 for SELENOP; 1785 for GPX3 and Se) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).
View Article and Find Full Text PDFArticle Synopsis
- A genome-wide study explored gene-environment interactions (G×E) to identify variants that could impact breast cancer risk, analyzing data from around 72,285 breast cancer cases and 80,354 controls.
- Researchers found two specific SNP-risk factor pairs that showed a significant association with breast cancer risk, including variations related to adult height and age at menarche.
- Overall, the study concluded that G×E interactions contribute minimally to the heritability of breast cancer and don't significantly enhance risk prediction for the disease.
Article Synopsis
- Polygenic risk scores (PRSs), derived from genome-wide association studies (GWASs), can enhance breast cancer risk evaluation but are primarily based on European populations.
- This study analyzed the effectiveness of European-based PRS models in identifying breast cancer risk among Ashkenazi Jewish women in Israel using data from two cohorts.
- Results indicated that these PRS models successfully identified Ashkenazi Jewish women at high risk for breast cancer, suggesting they could improve risk assessment in this group.
Background: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality.
Methods: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Background: Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI).
Methods: We evaluated body shape with the allometric "a body shape index" (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Preclinical and genetic studies suggest that impaired glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling worsens glycemic control. The relationship between GIPR signaling and the risk of cancers influenced by impaired glucose homeostasis is unclear. We examined the association of a variant in , rs1800437 (E354Q), shown to impair long-term GIPR signaling and lower circulating glucose-dependent insulinotropic peptide concentrations, with risk of 6 cancers influenced by impaired glucose homeostasis (breast, colorectal, endometrial, lung, pancreatic, and renal) in up to 235,698 cases and 333,932 controls.
View Article and Find Full Text PDFEvidence linking body fatness to breast cancer (BC) prognosis is limited. While it seems that excess adiposity is associated with poorer BC survival, there is uncertainty over whether weight changes reduce mortality. This study aimed to assess the association between body fatness and weight changes pre- and postdiagnosis and overall mortality and BC-specific mortality among BC survivors.
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- * Results showed that using estrogens with progesterone or dydrogesterone increased ovarian cancer risk (hazard ratio 1.28), while those with other progestagens showed a protective effect (hazard ratio 0.81).
- * The findings suggest that different MHT types have varying impacts on ovarian cancer risk, indicating a need for further research on the protective effects of certain progestagens.
Article Synopsis
- A study was conducted to explore how pre-diagnostic dietary patterns linked to inflammation, insulin, and estrogen affect survival rates in breast cancer (BC) patients.
- Researchers used dietary data from a large European study and applied statistical models to analyze the relationships between various diets and overall mortality as well as BC-specific mortality.
- The findings indicated that following a diabetes risk reduction diet (DRRD) was linked to lower overall mortality, while pro-inflammatory diets were associated with a slight increase in mortality; however, no significant link was found with estrogen-related diets or BC-specific mortality.
Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-hydroxyvitamin D [25(OH)D] to subsequent breast cancer incidence, we harmonized and pooled participant-level data from 10 U.S.
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