Publications by authors named "Laurane Leost"
Plutonium (Pu) is an anthropogenic element involved in the nuclear industry cycle. Located at the bottom of the periodic table within the actinide family, it is a chemical toxic but also a radiological toxic, regardless of isotopy. After nearly 80 years of Pu industrialization, it has become clear that inhalation and wounds represent the two main ways a person may become contaminated after an accident.
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- Traditional chelating agents like DTPA have been the go-to for removing actinides from the human body, but they mainly work in the blood serum.
- A new class of macromolecular decorporation agents is being explored for better effectiveness across different organs affected by plutonium.
- Polyethyleneimine methylenecarboxylate (PEI-MC) is a promising candidate because it can specifically target the liver and bones, improving treatment for organ contamination.
Since the 1940s, great amounts of Plutonium (Pu) have been produced for both military and civil purposes. Until now, the standard therapy for decorporation following inhalation has been the intravenous injection of diethylenetriaminepentaacetic acid ligand (Ca-DTPA form). This method offers a strong complexing constant for Pu(iv) but has poor chemical specificity, therefore its efficacy is limited to actinides present in the blood.
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