Publications by authors named "Laura-Marie Ammer"
TSPO is a promising novel tracer target for positron-emission tomography (PET) imaging of brain tumors. However, due to the heterogeneity of cell populations that contribute to the TSPO-PET signal, imaging interpretation may be challenging. We therefore evaluated TSPO enrichment/expression in connection with its underlying histopathological and molecular features in gliomas.
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- Glioblastoma (GB) IDH-wildtype is a highly aggressive brain tumor that shows significant resistance to immunotherapy, with the translocator protein 18 kDa (TSPO) playing a key role in this process.* -
- TSPO expression in GB cells correlates with immune infiltration and resistance to T cell-mediated killing, as it regulates apoptosis pathways and is upregulated in response to cytokines from T cells.* -
- Targeting TSPO may enhance the effectiveness of immunotherapy for GB by overcoming intrinsic resistance mechanisms and improving the sensitivity of cancer cells to immune attacks.*
Glioblastomas are highly malignant brain tumors that derive from brain-tumor-initiating cells (BTICs) and can be subdivided into several molecular subtypes. Metformin is an antidiabetic drug currently under investigation as a potential antineoplastic agent. The effects of metformin on glucose metabolism have been extensively studied, but there are only few data on amino acid metabolism.
View Article and Find Full Text PDFGlioblastoma (GBM) is the most fatal primary brain cancer in adults. Despite extensive treatment, tumors inevitably recur, leading to an average survival time shorter than 1.5 years.
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