Publications by authors named "Laura-Anne Grimbergen"
Article Synopsis
- RASopathies are genetic disorders linked to mutations in genes related to the RAS-ERK signaling pathway, leading to a range of intellectual disabilities, but their underlying mechanisms are not well understood.
- Costello syndrome, a specific type of RASopathy from HRAS mutations, was studied in HRas mice, revealing increased ERK signaling, neuronal growth, and learning difficulties, while other signaling changes seen in other RASopathies were not present.
- Treatments like lovastatin didn't improve cognitive issues in HRas mice, but a MEK inhibitor helped with some signaling problems without fixing the cognitive deficits, suggesting that different RASopathies may need tailored therapeutic approaches.
