Towards the Development of AgoKirs: New Pharmacological Activators to Study K2.x Channel and Target Cardiac Disease.

Inward rectifier potassium ion channels (I-channels) of the K2.x family are responsible for maintaining a stable negative resting membrane potential in excitable cells, but also play a role in processes of non-excitable tissues, such as bone development. I-channel loss-of-function, either congenital or acquired, has been associated with cardiac disease.