Publications by authors named "Laura de Lara-Pena"
Head and neck squamous cell carcinoma (HNSCC) presents a significant challenge worldwide due to its aggressiveness and high recurrence rates post-treatment, often linked to cancer stem cells (CSCs). Melatonin shows promise as a potent tumor suppressor; however, the effects of melatonin on CSCs remain unclear, and the development of models that closely resemble tumor heterogeneity could help to better understand the effects of this molecule. This study developed a tumor scaffold based on patient fibroblast-derived decellularized extracellular matrix that mimics the HNSCC microenvironment.
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- New research shows that cancer growth is affected by how stretchy and flexible tissues are, not just how stiff they are like people used to think.
- Current cancer studies mainly focus on stiffness and need to explore these new insights to help in diagnosing and treating cancer better.
- Scientists are using special gels to mimic body tissues and study how their stretchy properties affect cancer cells, which could lead to better ways to test and treat cancer.
Cancer stem cells (CSCs) play a significant role in driving several tumor hallmarks. Their behavior and tumor progression are strictly related to the tumor microenvironment (TME). The dynamic interplay between CSCs and TME drives metastasis, chemoresistance, and disease relapse.
View Article and Find Full Text PDFBreast cancer (BC) is the most diagnosed cancer in women and the second most common cancer globally. Significant advances in BC research have led to improved early detection and effective therapies. One of the key challenges in BC is the presence of BC stem cells (BCSCs).
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