The Fault in Our Sets: A Mixed Methods Analysis of Clinical Value Set Errors.

Objective: To characterize clinical value set issues and identify common patterns of errors.

Materials And Methods: We conducted semi-structured interviews with 26 value set experts and performed root cause analyses of errors identified in electronic health records (EHRs). We also analyzed a random sample of user-reported issues from the Value Set Authority Center (VSAC), developing a categorization scheme for value set errors.

Repurposing N-acetylcysteine for management of non-acetaminophen induced acute liver failure: an evidence scan from a global health perspective.

Background: The World Health Organization (WHO)'s Essential Medicines List (EML) plays an important role in advocating for access to key treatments for conditions affecting people in all geographic settings. We applied our established drug repurposing methods to one EML agent, N-acetylcysteine (NAC), to identify additional uses of relevance to the global health community beyond its existing EML indication (acetaminophen toxicity).

Methods: We undertook a phenome-wide association study (PheWAS) of a variant in the glutathione synthetase () gene in approximately 35,000 patients to explore novel indications for use of NAC, which targets glutathione.

Evidence for microtubule nucleation at the Golgi in breast cancer cells.

Golgi-derived microtubule (MT) arrays are essential to directionally persistent cell migration and vesicle transport. In this study, we have examined MT nucleation sites in two breast cancer cell lines, MDA-MB-231 and MCF-7, with the hypothesis that only the migratory invasive MDA-MB-231 cells exhibit MTs originating from the Golgi. MTs were disassembled and allowed to slightly regrow so individual nucleation sites could then be observed via fluorescently tagged antibodies (α-tubulin, cis-Golgi marker GM130, and EB1-a MT plus-end binding protein) and confocal microscopy.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

[Figure: see text].

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.

In Science Journals.

Highlights from the family of journals.