Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial.

Fluoxetine is the recommended first-line antidepressant in many therapeutic guidelines for children and adolescents. However, little is known about the relationships between drug dose and serum level as well as the therapeutic serum reference range in this age group. Within a large naturalistic observational prospective multicenter clinical trial ("TDM-VIGIL"), a transdiagnostic sample of children and adolescents ( = 138; mean age, 15; range, 7-18 years; 24.

The adaptation and evaluation of a CBT-based manual for the inpatient treatment of youth depression: a pilot study.

Background: Although there is good evidence to support the effectiveness of cognitive behavioral therapy (CBT) for the outpatient treatment of adolescent major depressive disorder (MDD), evidence-based manuals for the inpatient setting are lacking. This pilot study sought to (i) adapt an existing CBT manual (treatment of adolescent depression; TADS) to an inpatient setting (TADS-in), (ii) test its effectiveness at symptom reduction and remission of MDD in a pre-post design, and (iii) assess the strengths and limitations of the manual via a focus-group with clinicians.

Methods: Twenty nine adolescents aged 12-17 years with a primary ICD-10 diagnosis of MDD being treated as inpatients at a psychiatric clinic were included.

[Integrating the e-learning programme EGONE into the block of training in obstetrics and gynaecology].

Objective: EGONE is an E-Learning Forum for Gynaecology, Obstetrics, Neonatology and Reproductive Endocrinology based on the Swiss Catalogue of Learning Objectives. For two semesters, students attending the gynaecology block at the Medical Faculty of the University of Ulm have been provided with licences to use EGONE. Students can work on a specially equipped computer and practise whenever they want.

[Docs'n Drugs--an E-learning program for medical students; feasibility and evaluation of the acceptance in student training in child and adolescent psychiatry at the University Hospital in Ulm].

Objective: Increasingly widespread is the use of modern media such as E-learning in medical education. The Medical Faculty of the University of Ulm, being the Competence Center of E-learning, and the Competence Network in Medical Education in Baden-Württemberg have been developing a web based multimedia educational program since 1998.

Methods: In 2004 a grant for modular teaching projects sponsored by the Medical School was obtained in order to incorporate cases from Child and Adolescent Psychiatry into the Docs'n Drugs E-learning Module.

[Introduction of the module "Evidence-based Medicine" in Child and Adolescent Psychiatry into the psychiatry block practicum at the University of Ulm].

Objective: The essential need for the timely availability of additional relevant information has resulted in a focus on "Evidence-based Medicine" (EBM) in medical practice. In Child and Adolescent Psychiatry (CAP) training it is essential to impart knowledge of how to effectively use the available literature, since the evidence for many therapies is still poor.

Method: We modified the "Duke Model" for teaching EBM in CAP to better attune it to the educational needs of a German university.