p16, a marker of cellular senescence, is associated with renal disease in the B6. mouse model of lupus.

Objectives: Despite treatment, one-third of patients with lupus nephritis (LN) show a decline in renal function. Prognostic markers of poor outcome as well as novel therapeutic targets are therefore highly sought. We showed that p16, a marker of cellular senescence, is observed in baseline kidney biopsies from patients with LN, and is associated with renal disease.