Genotoxic and chemopreventive assessment of Cynara scolymus L. aqueous extract in a human-derived liver cell line.

Cynara scolymus L., popularly known as artichoke, is consumed as food and used as tea infusions for pharmacological purposes to treat liver dysfunctions and other conditions. Scientific data on the safety and protective effect of artichoke in human-derived liver cells is missing.

Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster.

The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the intercalating agent bleomycin (BLM), were examined using the somatic mutation and recombination test (SMART) in Drosophila melanogaster. Neither the mutagenicity nor the recombinogenicity of BLM or MMC was modified by co- or post-treatment with BHE or LE.

Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alterations in CHO cells.

Cynara scolymus L., popularly known as artichoke, has been widely used in traditional medicine as an herbal medicament for therapeutic purposes. The study aimed at assessing the protective activity of Cynara scolymus leaf extract (LE) against DNA lesions induced by the alkylating agent ethylmethnesulphonate (EMS) in Chinese hamster ovary cells (CHO).

Artichoke induces genetic toxicity in the cytokinesis-block micronucleus (CBMN) cytome assay.

Artichoke leaves are used in traditional medicine as an herbal medicament for the treatment of hepatic related diseases, as well as choleretic and diuretic. The aim of the present study was to evaluate the capacity of Cynara scolymus L. leaves extract (LE) to cause chromosomal instability and cytotoxicity in Chinese hamster ovary cells (CHO) employing the cytokinesis-block micronucleus (CBMN) cytome assay.

Artichoke induces genetic toxicity and decreases ethyl methanesulfonate-related DNA damage in Chinese hamster ovary cells.

Cynara scolymus L. (Asteraceae), popularly known as artichoke, has been widely used in herbal medicine for the treatment of hepatic diseases. The genotoxicity of C.

Recombinagenic activity of water and sediment from Sinos River and Araçá and Garças Streams (Canoas, Brazil), in the Drosophila wing spot test.

This study characterizes the likely interaction of surface water and sediment samples with DNA to quantitatively and qualitatively establish their mutagenic and/or recombinagenic activity. Samples were collected at 5 different sites within the area of Araçá Stream and 2 different sites within the Sinos River mouth and Garças Stream in the municipality of Canoas, RS, Brazil. The area is impacted by untreated urban discharges (sites 1-7), agricultural pesticides (sites 5 and 7), hospital waste (site 3), animal dejects (site 5), small industries (sites 4, 5 and 6) and vehicular discharges (sites 2, 4, 5 and 6).