Publications by authors named "Laura Vaca"
Latin American Challenges and Recommendations for Poly Adenosine Diphosphate Ribose Polymerase Inhibitor Treatment in Metastatic Castration Resistant Prostate Cancer: An Expert Overview.
Rodolfo Borges Dos Reis José L Aguilar-Ponce Federico Cayol Angela M Jansen Ray Manneh K Laura B Vaca
Cancer Control
October 2024
In Latin America, prostate cancer is the third most common cancer overall and the most common in men, with the highest mortality rate of all cancers. In 2022, there were approximately 22,985 new prostate cancer cases and 61,056 deaths from prostate cancer in the region. Patients with metastatic disease that is resistant to cure by castration now have multiple therapeutic options, including poly-ADP ribose polymerase inhibitors.
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- Semisynthetic functionalized triterpenes were created from a natural insecticide sourced from Euphorbia officinarum and then oxidized using hydrogen peroxide and iodosobenzene with porphyrin complexes to achieve derivatives with specific characteristics.
- The oxidation processes included epoxidation and hydroxylation, leading to several compounds with varying yields, such as 25-hydroxy derivatives and epoxides.
- Despite the low antifeedant effects observed against certain insects, these compounds showed significant post-ingestive toxic effects, particularly one compound that was more effective than the original insecticide, highlighting the importance of specific chemical groups in their activity.