Publications by authors named "Laura V Tsu"
Background: The Interprofessional Education Collaborative (IPEC) defined core competencies for IPE in 2011, and use of simulation in interprofessional education (IPE) continues to be developed in prelicensure health education programs.
Interprofessional Education Activity: In this prospective, observational study, interprofessional student teams addressed reversible causes of cardiac arrest in weekly simulations during an Emergency Medicine course. Each simulation was followed by sequential team debriefs, first regarding the IPEC core competencies of interprofessional communication, teamwork, and roles and responsibilities, and second regarding the patient-related content of the case.
Objective: To provide an up-to-date review of current hyperlipidemia guidelines and discuss pharmacotherapeutic management of hyperlipidemia in older individuals.
Data Sources: A PubMed search of articles published through October 2020 was performed using a combination of the following words: older adults, hyperlipidemia, statin, ezetimibe, fibrate, fish oil, niacin, bile acid sequestrant, and proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitor.
Study Selection/data Extraction: Relevant original research, review articles, and guidelines were assessed for the management of hyperlipidemia in the older individuals.
To provide an up-to-date review of current guidelines, previous trials, and new trials regarding aspirin use in primary prevention of cardiovascular (CV) disease in the elderly population. A PubMed search of articles published through April 2019 was performed using a combination of the following words: aspirin, bleeding, cardiovascular, elderly, hemorrhage, myocardial infarction, primary prevention, stroke. Relevant randomized controlled trials, meta-analyses, and guidelines were assessed for the use of aspirin in primary prevention of CV disease in older patients.
View Article and Find Full Text PDF To provide a review of the available evidence regarding pharmacotherapy and areas of pharmacist intervention in transitions of care (TOC) for the geriatric population with heart failure (HF).
A PubMed search of articles published from 1995 through July 2018 was performed using a combination of the following words: heart failure, geriatric, elderly, (TOC), multidisciplinary, pharmacist.
Relevant original research, review articles, and guidelines were assessed for the management of elderly patients with HF.
: To provide an up-to-date review of current hypertension (HTN) guidelines and discuss pharmacotherapeutic management of HTN in the older adult population.
: A PubMed search of articles published through June 2018 was performed using a combination of the following words: elderly, older adults, geriatric, and HTN.
: Relevant original research, review articles, and guidelines were assessed for the management of HTN in older adults.
Objective To provide an up-to-date review of the available evidence regarding pharmacotherapeutic management of venous thromboembolic events in the geriatric population. Data Sources A PubMed search of articles published through August 2017 was performed using a combination of the following words: apixaban, betrixaban, dabigatran, edoxaban, enoxaparin, geriatric, heparin, idaricizumab, rivaroxaban, and venous thromboembolism. Study Selection/data Extraction Relevant original research, review articles, and guidelines were assessed for the management of elderly patients with venous thromboembolism (VTE).
View Article and Find Full Text PDFObjective: To provide an up-to-date review of the available evidence regarding management of elderly patients after transcatheter aortic valve replacement (TAVR).
Data Sources: A PubMed search of articles published (September 1969-December 2016) was done using a combination of the following words: aortic valve stenosis, geriatric, elderly, transcatheter aortic valve replacement, surgical aortic valve replacement, transcatheter aortic valve implantation (TAVI), and dual antiplatelet therapy.
Study Selection/data Extraction: Relevant original research, review articles, and guidelines were assessed for the management of elderly patients after TAVR.
Objective: To determine if a modified HAS-BLED score (hypertension, abnormal renal/liver dysfunction, stroke, bleeding history, elderly, drugs) predicts risk for major bleeding in patients prescribed dabigatran or rivaroxaban.
Design: A retrospective, case-control study.
Setting: Two inpatient medical centers.
Objective: To provide an up-to-date review of the available evidence regarding treatment of acute coronary syndromes (ACS) in elderly patients.
Data Source: A PubMed search of articles published through January 2015 was done using a combination of the following words: acute coronary syndrome, pharmacy, elderly, geriatric, myocardial infarction, beta-blocker, statin, antiplatelet, antithrombin, angiotensin-converting enzyme inhibitor, and aspirin.
Study Selection/data Extraction: Relevant original research, review articles, and guidelines were assessed for the management of elderly patients with ACS.
In the setting of end-stage kidney disease, the incidence and risk for thrombotic events are increased and use of anticoagulants is common. The incidence of bleeding, however, is also a frequent issue and creates additional challenges in the management of anticoagulation therapy. Patients with end-stage renal disease are typically excluded from large clinical trials exploring the use of anticoagulants, which limits our knowledge of optimal management approaches.
View Article and Find Full Text PDFUpdates in antiarrhythmic therapy for atrial fibrillation in geriatric patients.
Consult Pharm
February 2015
Objective: To provide a review of the current evidence for the use of antiarrhythmic therapy in the geriatric population.
Data Sources: A PubMed search of articles in the English language published from 1990 through August 2014 was performed using a combination of the following words: amiodarone, antiarrhythmic, atrial fibrillation, dofetilide, dronedarone, elderly, flecainide, geriatric, propafenone, sotalol.
Study Selection/data Extraction: Relevant original studies, review articles, and guidelines were assessed for use of antiarrhythmic therapy to manage atrial fibrillation (A fib) in the elderly.
Objective: To determine the evidence for use of ranolazine for treatment and prevention of postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery.
Data Sources: A literature search of MEDLINE (1946 to January 2014) was conducted, using the search terms ranolazine, atrial fibrillation, and cardiac surgery. A search of reference citations was conducted to identify additional references.
Objective: To determine the safety of dabigatran, rivaroxaban, or apixaban with dual antiplatelet therapy in patients with acute coronary syndromes.
Data Sources: A literature search of MEDLINE (1946-January 2013) was conducted, using the search terms dabigatran, rivaroxaban, or apixaban in combination with dual antiplatelet therapy. A search of literature citations was conducted to identify additional references.
Article Synopsis
- Vitamin K is essential for reversing the effects of warfarin, but there's uncertainty around the best dosage and method to avoid prolonging bridging therapy duration.
- A study reviewed the medical charts of 400 patients to examine how vitamin K influences INR reversal in an acute care setting, focusing on factors like dosage, administration route (IV or oral), and pre-treatment INR levels.
- Results indicated that intravenous vitamin K is more effective than oral in reducing INR levels, with factors such as the initial INR and vitamin K dosage significantly affecting outcomes; however, the type of administration and baseline warfarin dose did not appear to impact the results significantly.
Article Synopsis
- The study aimed to evaluate different dosing strategies for bivalirudin in treating heparin-induced thrombocytopenia (HIT) in obese versus nonobese patients, using total body weight, adjusted body weight, and ideal body weight.
- Conducted as a retrospective review at an academic medical center, the study analyzed 135 patients based on their body mass index (BMI) and compared dosing outcomes.
- Results indicated that total body weight and adjusted body weight dosing were most effective for reaching the target activated partial thromboplastin time (aPTT) in obese patients, while initial dosing varied between obese and nonobese groups without significant differences in clinical outcomes related to aPTT achievement.
Background: While not approved by the Food and Drug Administration for treatment of heparin-induced thrombocytopenia (HIT), except in patients undergoing percutaneous interventions, the direct thrombin inhibitor bivalirudin is a treatment option that is gaining use. An initial dose of bivalirudin 0.15-0.
View Article and Find Full Text PDFObjective: To describe management of anticoagulation with a decreased dose requirement of bivalirudin during cardiopulmonary bypass using deep hypothermic circulatory arrest (DHCA) and the reversal of the ensuing coagulopathy with recombinant factor VIIa (rFVIIa).
Case Summary: A 48-year-old male developed chest pain, hypertension, and an aortic aneurysm requiring urgent surgical repair. At the time of surgery, the patient reported an allergy to heparin, so bivalirudin was used for anticoagulation (1 mg/kg loading dose, followed by intermittent infusions of 1.