Heterogeneity of Randomized Controlled Trials of Fecal Microbiota Transplantation in Recurrent Clostridioides difficile Infection.

Introduction: Clinical trials have demonstrated the efficacy of FMT for reduction in CDI recurrences (rCDI), but this treatment and its reporting in the literature has significant heterogeneity. Recent publications (e.g.

Insights from Real-World Analysis of Treatment Patterns in Patients with Newly Diagnosed Knee Osteoarthritis.

Background: Several nonpharmacologic and pharmacologic treatments are available for the management of knee osteoarthritis (OA)-related pain and for improving functionality; however, clinical guideline recommendations vary on their use.

Objective: To compare the treatment patterns in a real-world setting versus the guideline recommendations for the treatment of newly diagnosed patients with knee OA.

Methods: This retrospective analysis used data from the electronic health records of the Geisinger Health System between January 1, 2010, and December 2018 to identify adults with newly diagnosed knee OA who had not received previous therapy with intra-articular corticosteroids, opioids, intra-articular hyaluronic acid, or prescription nonsteroidal anti-inflammatory drugs (NSAIDs).

Real-world experience with intravaginal culture using INVOCELL: an alternative model for infertility treatment.

Objective: To describe the current practice indications, methodology, and outcomes from a real-world experience of intravaginal culture (IVC) using INVOCELL.

Design: A descriptive study outlining real-world experience with INVOCELL that addresses patient selection, ovarian stimulation, embryology laboratory practices, and outcomes.

Setting: Five fertility centers in Missouri, Texas, North Carolina, South Carolina, and Virginia.

Clinical complications in patients with primary and recurrent infection: A real-world data analysis.

Objective: infection and recurrent infection result in substantial economic burden and healthcare resource use. Sepsis and bowel surgery are known to be serious complications of infection. This study evaluated clinical complications in patients with infection and recurrent infection during a 12-month period following the primary infection.

Healthcare resource utilization and direct medical costs associated with index and recurrent infection: a real-world data analysis.

This study aimed to evaluate all-cause economic outcomes, healthcare resource utilization (HRU), and costs in patients with infection (CDI) and recurrent CDI (rCDI) using commercial claims from a large database representing various healthcare settings. A retrospective analysis of commercial claims data from the IQVIA PharMetrics Plus database was conducted for patients aged 18-64 years with CDI episodes requiring inpatient stay with CDI diagnosis code or an outpatient medical claim for CDI plus a CDI treatment. Index CDI episodes occurred between 1 January 2010 and 30 June 2017, including only those where patients were observable 6 months before and 12 months after the index episode.