Publications by authors named "Laura Showalter"
Article Synopsis
- - The study examines a new mucosal vaccine strategy against SARS-CoV-2 variants, showing that intranasal and oral delivery of a non-replicating adenovirus-vectored vaccine can induce stronger immune responses compared to standard vaccinations.
- - Hamsters vaccinated with the Wuhan variant vaccine before being exposed to the delta or omicron variants showed protection from weight loss and lung damage, reducing viral shedding significantly.
- - The research suggests that mucosal vaccines might provide broader and more effective immunity against various SARS-CoV-2 variants, indicating they could be a promising approach to curtailing viral transmission and the emergence of new variants.
Background And Purpose: Patients with severe obstructive sleep apnea (OSA) have an almost 4-fold higher odds of resistant hypertension than those with less severe OSA. Obstructive sleep apnea screening practices in primary care are deficient. Additional study is needed regarding the value of OSA screening in hypertensive adults who present to the primary care clinic.
View Article and Find Full Text PDFHuman immunodeficiency virus (HIV) infection continues to pose a major infectious disease threat worldwide. It is characterized by the depletion of CD4 T cells, persistent immune activation, and increased susceptibility to secondary infections. Advances in the development of antiretroviral drugs and combination antiretroviral therapy have resulted in a remarkable reduction in HIV-associated morbidity and mortality.
View Article and Find Full Text PDFCertain viruses have the ability to subvert the mammalian immune response, including interference in the chemokine system. Poxviruses produce the chemokine binding protein vCCI (viral CC chemokine inhibitor; also called 35K), which tightly binds to CC chemokines. To facilitate the study of vCCI, we first provide a protocol to produce folded vCCI from (.
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