Publications by authors named "Laura Schaupp"
Article Synopsis
- The use of "Wildling mice" with a natural microbiome presents a unique research tool for studying human-like immune systems, but poses challenges for animal husbandry due to their diverse microbial content.
- A specialized facility was created at Charité - Universitätsmedizin Berlin to manage these mice, incorporating unique designs and protocols for hygiene and microbiome containment.
- The study shows that "Wildling mice" develop distinct immune cell populations compared to SPF mice, suggesting that using these mice could improve the relevancy of preclinical findings for human health.
Article Synopsis
- Recent studies showed that the triple combination CFTR modulator therapy, elexacaftor/tezacaftor/ivacaftor (ETI), enhances lung function and reduces flare-ups in cystic fibrosis (CF) patients with at least one CFTR allele, but its impact on mucus properties, infection, and inflammation was previously unexplored.
- This study tracked changes in mucus rheology, microbiome, and inflammation markers in CF patients aged 12 and older over the first year of ETI therapy.
- Results indicated that ETI significantly improved mucus properties, increased microbiome diversity, and reduced inflammation markers, suggesting ETI positively affects airway health, but did not fully normalize conditions to levels seen in healthy individuals.
Environmental signals shape host physiology and fitness. Microbiota-derived cues are required to program conventional dendritic cells (cDCs) during the steady state so that they can promptly respond and initiate adaptive immune responses when encountering pathogens. However, the molecular underpinnings of microbiota-guided instructive programs are not well understood.
View Article and Find Full Text PDF