Protective Efficacy of Inhaled BCG Vaccination Against Ultra-Low Dose Aerosol Challenge in Rhesus Macaques.

Ten million cases of tuberculosis (TB) were reported in 2018 with a further 1.5 million deaths attributed to the disease. Improved vaccination strategies are urgently required to tackle the ongoing global TB epidemic.

ELISPOT Refinement Using Spot Morphology for Assessing Host Responses to Tuberculosis.

Tuberculosis is a global health problem. The Mycobacterium bovis Bacille Calmette Guerin (BCG) vaccine has variable efficacy (0-80%) so there is a drive to develop novel vaccines. The cytokine, interferon gamma (IFNγ), is an essential component of the protective response to M.