Publications by authors named "Laura Robustelli Test"
Previous studies suggested that hypertensive patients with left ventricular (LV) hypertrophy display right ventricular (RV) remodelling. Few data are available about RV remodelling in naive hypertensives without severe cardiac organ damage. Our aim was to evaluate the relationship between RV and LV morpho-functional parameters in never-treated patients with grade 1 hypertension and whether central blood pressure (CBP), inflammatory and metabolic parameters are potentially associated with RV remodelling.
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- The study examines the differences in CD4+ T-cell subsets between dyslipidemic patients and healthy subjects, focusing on the regulatory T cells (CD4+ CD25(high)FoxP3+) and their response to atorvastatin treatment.
- The results indicate that while CD4+ CD25(high)FoxP3+ cells were more prevalent in patients, their frequency remained unchanged during atorvastatin therapy, and other cell functions were not significantly modified in vitro.
- Findings suggested a correlation between CD4+ CD25(high)FoxP3+ cells and cholesterol levels, highlighting their potential role in atherosclerosis development, although statin treatment did not achieve the expected immuno-modulation in these T-cell subsets.
Background: Neutrophil (PMN) leukocytes participate to the initial phases of atherosclerosis through the release of Interleukin 8 (CxCL8; IL-8) that contribute to amplification of inflammation. Aim of the study is to investigate the production of IL-8 by PMN leukocytes from dyslipidemic patients treated with simvastatin.
Methods: In 15 dyslipidemic subjects with moderately increased cardiovascular risk, assessed by Framingham Risk Score, blood samples were obtain to investigate PMNs IL-8 production [at baseline and after N-formyl-Met-Leu-Phe (fMLP) stimulation] before and after long-term (1-year) simvastatin treatment.