The impact of religiousness and beliefs about mental illness on help-seeking behaviors of Muslim Americans.

Background: In addition to the typical challenges of daily life, Muslim Americans have experienced high levels of stress and clinical disorders relating to discrimination from the 9/11 attacks and ongoing political stigma. Despite mounting mental health concerns, Muslim Americans have encountered multifaceted barriers to accessing mental health services and remain underserved.

Aims: This study sought to explore the relationship between religiousness and beliefs about mental illness among Muslim Americans to predict their clinical help-seeking attitudes.

The More You Know: Sexual Knowledge as a Predictor of Sexual Well-Being.

The World Health Organization (WHO), defines sexual well-being as a multifaceted construct, consisting of more than absence of disease or experiences of pleasure. Further, the WHO suggests that sexual knowledge should contribute to sexual well-being. We examined the relationship between personal sexual knowledge-knowing one's individual sexual preferences-and sexual health knowledge-awareness of reproduction, contraception, and diseases-and sexual well-being, comprised of sexual satisfaction, assertiveness, and competence in a sample of 484 emerging adults.

Do Concepts of Depression Predict Treatment Pathways? A Closer Look at Explanatory Models Among Clinical and Nonclinical Samples in Uganda.

Objective: Explanatory models (EMs) are a collection of beliefs about a disorder that can help us understand help-seeking and treatment pathways in diverse contexts. In 2 related studies, we explore EMs about depression held among both clinical and nonclinical samples in Uganda. To explore the potential of EMs to predict help seeking, we assessed the relationship between 2 main aspects of the EM: problem conceptualization and treatment.

Measuring social desirability across language and sex: A comparison of Marlowe-Crowne Social Desirability Scale factor structures in English and Mandarin Chinese in Malaysia.

Malaysia is a Southeast Asian country in which multiple languages are prominently spoken, including English and Mandarin Chinese. As psychological science continues to develop within Malaysia, there is a need for psychometrically sound instruments that measure psychological phenomena in multiple languages. For example, assessment tools for measuring social desirability could be a useful addition in psychological assessments and research studies in a Malaysian context.

Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability.

G protein-coupled receptor kinases (GRKs) act to desensitize G protein-coupled receptors (GPCRs). In addition to this role at the plasma membrane, a nuclear function for GRK5, a member of the GRK4 subfamily of GRKs, has been reported. GRK5 phosphorylates and promotes the nuclear export of the histone deacetylase, HDAC5.

Salmonella infections associated with international travel: a Foodborne Diseases Active Surveillance Network (FoodNet) study.

Salmonella species cause an estimated 1.2 million infections per year in the United States, making it one of the most commonly reported enteric pathogens. In addition, Salmonella is an important cause of travel-associated diarrhea and enteric fever, a systemic illness commonly associated with Salmonella serotypes Typhi and Paratyphi A.

GDP-mannose transporter paralogues play distinct roles in polarized growth of Aspergillus nidulans.

GDP-mannose transporters (GMT) carry GDP-mannose nucleotide sugars from the cytosol across the Golgi apparatus membrane for use as substrates in protein glycosylation in plants, animals and fungi. Genomes of some fungal species, such as the yeast Saccharomyces cerevisiae, contain only one gene encoding a GMT, while others, including Aspergillus nidulans, contain two (gmtA and gmtB). We previously showed that cell wall integrity and normal hyphal morphogenesis in A.

Contrasting concepts of depression in Uganda: implications for service delivery in a multicultural context.

Depression is a rising public health concern worldwide. Understanding how people conceptualize depression within and across cultures is crucial to effective treatment in a global environment. In this article, we highlight the importance of considering both lay and professional perspectives when developing a culturally competent and contextually relevant model for service delivery.

G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence.

G protein-coupled receptor kinases (GRKs) mediate desensitization of agonist-occupied G protein-coupled receptors (GPCRs). Here we report that GRK5 contains a DNA-binding nuclear localization sequence (NLS) and that its nuclear localization is regulated by GPCR activation, results that suggest potential nuclear functions for GRK5. As assessed by fluorescence confocal microscopy, transfected and endogenous GRK5 is present in the nuclei of HEp2 cells.

Stable expression and characterisation of a human alpha 7 nicotinic subunit chimera: a tool for functional high-throughput screening.

A chimera comprising the N-terminal region of the human alpha7 nicotinic acetylcholine receptor, fused to the transmembrane/C-terminal domains of the mouse serotonin 5-HT3 receptor, was constructed. Injection of the chimera cDNA into Xenopus oocytes, or transient transfection in human embryonic kidney (HEK-293) cells, resulted in the expression of functional channels that were sensitive to nicotinic acetylcholine, but not serotonin receptor ligands. In both systems, the responses obtained from chimeric receptors inactivated more slowly than those recorded following activation of wild-type alpha7 receptors.

XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk.

Cigarette smoking is the main risk factor for bladder cancer, accounting for at least 50% of bladder cancer in men. Cigarette smoke is a rich source of arylamines, which are detoxified by the NAT2 enzyme and activated by the NAT1 enzyme to highly reactive species that can form bulky adducts on DNA. DNA damage from such adducts is mainly repaired by the nucleotide excision repair pathway, in which the XPD protein functions in opening the DNA helix.