Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores.

Nutrigenetic studies analyzing gene-diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by obesity. Moreover, TCF7L2-rs7903146 is one of the most influential variants in T2D-genetic risk scores (GRS).

[SHORT TERM EFFECTS ON LIPID PROFILE AND GLYCAEMIA OF A LOW-FAT VEGETARIAN DIET].

Introduction: vegetarian diets have been associated with lower risk of cardiovascular disease and a more favourable lipid profile in vegetarians who follow these diets for a long term period in observational studies, but the short-term effects of vegetarian diets are less known.

Objective: our objective was to analyze the short-term effects of a low-fat vegetarian diet on lipid profile and fasting glucose in previously non-vegetarian subjects from a Mediterranean population.

Methods: we carried out a nutritional intervention study in 159 volunteers (42 men and 117 women).