Total hip replacement after failed femoral head and neck excision in two dogs and two cats.

Objective: To document outcome in 2 dogs and 2 cats after conversion of femoral head and neck excision (FHNE) to total hip replacement (THR).

Study Design: Case series.

Animals: Dogs (n = 2) and 2 cats.

Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease.

It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease. In this study we sought to characterize the relationship between demyelination, inflammation and axonal transport changes using a Plp1-transgenic mouse model of Pelizaeus-Merzbacher disease. In the optic pathway of this non-immune mediated model of demyelination, myelin loss progresses from the optic nerve head towards the brain, over a period of months.