Publications by authors named "Laura Porcel"
Article Synopsis
- Multiple system atrophy (MSA) is a neurodegenerative disease characterized by abnormal protein aggregation, resulting in symptoms like dysautonomia, parkinsonism, and ataxia.
- This study aimed to assess the accuracy of diagnostic criteria for MSA, emphasizing the role of new MRI markers in diagnosis.
- Results showed that while the criteria had high specificity (99-100%), their sensitivity was low initially but improved over time; excluding MRI features from the criteria significantly increased sensitivity without affecting specificity.
Article Synopsis
- Scientists studied over 176,000 people to see how certain genes might protect against Parkinson's disease (PD) and Alzheimer's disease (AD).
- They found that specific types of a gene called HLA could help reduce the risk of these diseases and lower harmful proteins in the brain.
- This suggests that our immune system might help protect us from PD and AD, which could lead to new treatments in the future.
Article Synopsis
- An estimated 40% of dementia cases might be preventable by altering 12 specific risk factors throughout a person's life, although there's insufficient evidence for many of them.
- The study aims to identify causal relationships between modifiable risk factors for Alzheimer’s disease (AD) to encourage new treatment options and better prevention strategies.
- Researchers analyzed data from over 39,000 AD patients and 401,000 controls, finding that higher genetically determined levels of HDL cholesterol and systolic blood pressure were linked to an increased risk of developing AD.
Objectives: The prevalence, clinical characteristics and prognosis of pleural effusions (PEs) associated with ovarian cancer (OC) have seldom been addressed systematically, as in the current investigation.
Methods: All records of consecutive women with a newly diagnosed OC in our institution over a 13-year period were retrospectively reviewed. Features of PEs on CT scans, pleural fluid analyses, need for definitive therapy of PEs, and the influence of PEs on the overall survival (OS) and progression-free survival (PFS) were evaluated.