Human mass balance study of TAS-102 using (14)C analyzed by accelerator mass spectrometry.

Background: TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio. FTD is a thymidine analog, and it is degraded by thymidine phosphorylase (TP) to the inactive trifluoromethyluracil (FTY) metabolite.

A multicenter study of key stakeholders' perspectives on communicating with surrogates about prognosis in intensive care units.

Rationale: Surrogates of critically ill patients often have inaccurate expectations about prognosis. Yet there is little research on how intensive care unit (ICU) clinicians should discuss prognosis, and existing expert opinion-based recommendations give only general guidance that has not been validated with surrogate decision makers.

Objective: To determine the perspectives of key stakeholders regarding how prognostic information should be conveyed in critical illness.

Nurse-led intervention to improve surrogate decision making for patients with advanced critical illness.

Background: Problems persist with surrogate decision making in intensive care units, leading to distress for surrogates and treatment that may not reflect patients' values.

Objectives: To assess the feasibility, acceptability, and perceived effectiveness of a multifaceted, nurse-led intervention to improve surrogate decision making in intensive care units.

Study Design: A single-center, single-arm, interventional study in which 35 surrogates and 15 physicians received the Four Supports Intervention, which involved incorporating a family support specialist into the intensive care team.