Rapid progression to gummatous syphilitic hepatitis and neurosyphilis in a patient with newly-diagnosed HIV.

We review the literature on hepatic involvement in patients with HIV and syphilis co-infection and describe a case of rapid progression to neurosyphilis and presumed gummatous syphilitic hepatitis in a patient newly diagnosed with HIV. To our knowledge, this is the first case of syphilitic hepatitis with gummas described in the HIV population.

Intensive hemodialysis compared to conventional hemodialysis: looking at recent evidence in an old debate.

Despite a significant research effort, the optimal dialysis regimen remains a topic of major controversy. There is a growing interest in intensive hemodialysis regimens as they have been associated with positive outcomes in several observational studies. However, recent evidence from a large cohort study casts doubts on the benefits of intensive hemodialysis.

Fraternal twins with Aarskog-Scott syndrome due to maternal germline mosaicism.

Aarskog-Scott syndrome is a rare X-linked recessive disorder with characteristic facial, skeletal, and genital abnormalities. We report on Aarskog-Scott syndrome in male dizygotic twins with an identical de novo mutation in FGD1 that resulted from germline mosaicism in the phenotypically normal mother. This is the first report of inheritance by germline mosaicism for the FGD1 gene.