Publications by authors named "Laura Petrikowski"
Introduction: Omphalocele represents a rare congenital abdominal wall defect. In giant omphalocele, due to the viscero-abdominal disproportion, gradual reintegration of eviscerated organs is often associated with medical challenges. We report our preliminary experience combining staged gravitational reduction with vacuum (VAC) therapy as a novel approach for treatment of giant omphalocele.
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- * A study using double-transgenic mice (2D2/Th) with spontaneous opticospinal encephalomyelitis (OSE) showed that these mice developed retinal thinning and impaired photoreceptor function, indicating visual system degeneration.
- * Findings revealed increased inflammation in the optic nerves and retinas, including higher levels of immune cells and upregulation of the complement system, highlighting both inflammatory and degenerative processes in the visual system of OSE mice
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo and in 2D2 mice, which harbor a transgenic MOG-specific T-cell receptor.
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- - Laquinimod, an oral immunomodulatory agent being tested for multiple sclerosis treatment, shows promise in reducing degenerative processes in the optic nerve and retina, which are often impacted by MS.
- - In a study using C57/BL6 mice with induced experimental autoimmune encephalomyelitis, laquinimod treatment led to decreased neurological symptoms, reduced cellular infiltration and demyelination in the optic nerve, and improved retinal neuron function.
- - The results indicate that laquinimod preserves retinal ganglion cells and reduces apoptosis, with both preventive and therapeutic treatments showing improved outcomes, including enhanced electrical signals from retinal cells.