Clinical and economic impact of first-line or drug-naïve catheter ablation and delayed second-line catheter ablation for atrial fibrillation using a patient-level simulation model.

Aims: To determine the clinical and economic implications of first-line or drug-naïve catheter ablation compared to antiarrhythmic drugs (AADs), or shorter AADs-to-Ablation time (AAT) in atrial fibrillation (AF) patients in France and Italy, using a patient level-simulation model.

Materials And Methods: A patient-level simulation model was used to simulate clinical pathways for AF patients using published data and expert opinion. The probabilities of adverse events (AEs) were dependent on treatment and/or disease status.

Light-dependent inhibition of clathrin-mediated endocytosis in yeast unveils conserved functions of the AP2 complex.

Clathrin-mediated endocytosis (CME) is an essential cellular process, conserved among eukaryotes. Yeast constitutes a powerful genetic model to dissect the complex endocytic machinery, yet there is a lack of specific pharmacological agents to interfere with CME in these organisms. TL2 is a light-regulated peptide inhibitor targeting the AP2-β-adaptin/β-arrestin interaction and that can photocontrol CME with high spatiotemporal precision in mammalian cells.

Coupled sterol synthesis and transport machineries at ER-endocytic contact sites.

Sterols are unevenly distributed within cellular membranes. How their biosynthetic and transport machineries are organized to generate heterogeneity is largely unknown. We previously showed that the yeast sterol transporter Osh2 is recruited to endoplasmic reticulum (ER)-endocytic contacts to facilitate actin polymerization.

(1,2-Azole)bis(bipyridyl)ruthenium(II) Complexes: Electrochemistry, Luminescent Properties, And Electro- And Photocatalysts for CO Reduction.

New -(1,2-azole)-aquo bis(2,2'-bipyridyl)ruthenium(II) (1,2-azole (az*H) = pzH (pyrazole), dmpzH (3,5-dimethylpyrazole), and indzH (indazole)) complexes are synthesized via chlorido abstraction from -[Ru(bipy)Cl(az*H)]OTf. The latter are obtained from -[Ru(bipy)Cl] after the subsequent coordination of the 1,2-azole. All the compounds are characterized by H, C, N NMR spectroscopy as well as IR spectroscopy.

Suprasellar ganglioglioma presenting as a middle cerebral artery infarction.

Background: Gangliogliomas are a relatively rare neoplasm with a major incidence in the pediatric population. As the temporal lobes are the most common site, patients usually present with seizures.

Case Report: We report the case of a 9-year-old child with an extensive suprasellar ganglioglioma presenting with a cerebral infarction due to direct compression of the medium cerebral artery.

Sex-dependent gene expression after ochratoxin A insult in F344 rat kidney.

Ochratoxin A (OTA) is a potent rodent nephrocarcinogen; being males more sensitive than females. The objective was to study the response between sexes at gene expression level (whole genome transcriptomics) in kidneys of F344 rats treated with 0.21 or 0.

Is oxidative stress involved in the sex-dependent response to ochratoxin A renal toxicity?

Ochratoxin A (OTA) is a mycotoxin considered the most powerful renal carcinogen in rodents and classified as a possible human carcinogen. Though its mechanism of action is still unknown, indirect DNA reactivity mediated by oxidative stress has been hypothesized to play an important role. Moreover, large sex-differences have been observed in carcinogenicity studies, male rats being more sensitive than females.

Sex differences in ochratoxin a toxicity in F344 rats after 7 and 21 days of daily oral administration.

Ochratoxin A (OTA) is a potent renal carcinogen in male rats but not in females. The mechanisms underlying these differences are unknown. The sex-dependent response of F344 rats after a repeated OTA oral administration for 7 (0.

Gene expression kinetics of renal transporters induced by ochratoxin A in male and female F344 rats.

Ochratoxin A (OTA) is a mycotoxin that contaminates foodstuffs. The most relevant concern is its high kidney carcinogenicity in male rats and its unclear mechanism of action. It has been hypothesized that variations in transport mechanisms in kidney cells may be the reason of different sex-dependent sensitivities towards OTA.

Multi-parametric system for the continuous assessment and monitoring of motor status in Parkinson's disease: an entropy-based gait comparison.

A "Multi-parametric system for the continuous assessment and monitoring of motor status in Parkinson's disease" (PERFORM), is an FP7 project from the European Commission that aims at providing an innovative and reliable tool, able to evaluate, monitor and manage patients suffering from motor neurodegenerative diseases. The current work is related to a module of the project that is in charge of assessing PD patients during locomotion. These initial analyses of gait are based on analyses of Sample Entropy in the acceleration signals.